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A landmark review by Pickart and Margolina in Biomolecules confirming GHK-Cus broad gene regulatory influence on tissue repair pathways supports its complementary role alongside metabolic interventions like NAD+ therapy

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These hormonal effects contribute to its potential anti-aging and stress-reduction benefits but also warrant caution for those with hormone-sensitive conditions

Many larger health claims regarding longevity, organ regeneration and disease treatment are yet to undergo large scale human clinical trials

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